Type of Cancer Acute lymphocytic leukemia, Hodgkin's and non-Hodgkin's lymphoma, neuroblastoma, testis, sarcomas, lung, breast, cervix, Wilms' tumor 
Route Administered Intravenous 
Precautions Take care not to leak from IV site (irritating), constipation program 
Side Effects Severe reaction with IV leak, numbness, tingling fingers and feet, hair loss, loss of nerve function (foot drop and partial paralysis), low blood counts, nausea, vomiting, constipation, sore mouth and throat, difficulty chewing or swallowing, dry mouth, altered taste and smell, increased uric acid (gout)